Santos, N., Suuronen, E.J., Alarcon, E.I., Ahumada, M. (2026). Biomolecule Silver Nanoparticle-Based Materials for Biomedical Applications. In: Martínez, L.M.T., Kharissova, O.V., Kharisov, B.I. (eds) Handbook of Ecomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-48281-1_161-2

Abstract: Silver nanoparticles have quickly established themselves as a multifaceted nanomaterial in the biomedical field, with their properties widely studied over the last decade. However, there are still concerns regarding its long-term toxicity. Recent developments in nanoparticle fabrication and surface manipulation using various biomolecules have enabled the preparation of nontoxic nanosilver. Thus, nanosilver has been safely incorporated into a variety of regenerative templates for the engineering of tissues such as the cornea, skin, and heart. In addition, it has been incorporated into wound-healing treatments, biosensors, and imaging modalities, among others. In this chapter, a selection of promising synthetic routes for the preparation of biomolecule-capped silver nanoparticles will be discussed and presented. The main goal is to present a rationale for choosing a synthetic route for nanosilver that minimizes/avoids toxic side effects for biomaterial development.